Michael Polansky, co‑founder of Outer Biosciences, said his company is training an artificial intelligence model using human skin tissue that can be maintained for up to 30 days.
Outer Biosciences obtains discarded surgical skin samples from nonprofit and commercial biobanks that operate under institutional review board oversight and documented donor consent. The samples are supplied de‑identified and are kept viable by a proprietary system that delivers nutrients and removes waste, extending their functional life far beyond the typical industry duration of a few days.
The AI model predicts how untested chemicals will affect specific skin functions; these predictions are applied to the living tissue, and the resulting data are fed back into the model to refine future forecasts. Since incorporating AI, the company has generated a new candidate roughly every six weeks, with six candidates currently in its pipeline and dozens of additional leads recorded.
The company has raised about $23 million from investors including Wing Ventures, Initialized, and Hawktail and employs 19 people, most based near Cambridge, Massachusetts. Outer Biosciences plans to license its ingredients to cosmetics or pharmaceutical firms rather than market a consumer brand. It also collaborates with Haus Labs, the cosmetics company founded by Stefani Germanotta, and its chief scientist sits on Haus Labs’ scientific advisory board.
Other firms, such as Vivodyne, have raised close to $80 million to develop organ‑tissue technologies, while several startups pursue organ‑on‑chip systems. Polansky said Outer Biosciences’ use of actual tissue distinguishes its approach and that its on‑premise AI infrastructure reduces cloud dependency.
Polansky said the ultimate goal is a predictive model accurate enough to identify promising skin‑biology directions without requiring every experiment to be performed physically, potentially accelerating discovery in dermatology. He added that the team intends to operate more publicly as the data accumulate, though product development and manufacturing remain manual.

