A 1993 murder in Granite City, Illinois, was solved after investigators used genetic genealogy and artificial intelligence to identify a suspect, authorities said.
Gail Sperino, 34, was found dead in a field on November 9, 1993, after being blunt-force trauma victim. Her case remained unsolved for three decades despite extensive interviews and DNA testing that yielded no matches in standard law enforcement databases.
In 2023, Madison County detectives submitted crime scene DNA to Othram, a Houston-based firm that applies investigative genetic genealogy. The technique analyzes distant genetic relatives from public genealogy databases, building family trees to narrow down potential suspects. This approach, inspired by the 2018 identification of the Golden State Killer, allowed investigators to focus on Albert "Buddy" Zigler, 70, after DNA from his relatives linked him to the crime scene.
Captain Tim Lawrence of the Madison County Sheriff's Office confirmed that the genetic lead led to Zigler’s arrest in May 2024. He confessed to the murder, and Wes Sperino, Gail’s son, expressed relief at finally having closure.
The case also involved Centerline AI, a software platform from CentralSquare, which analyzed over 2,000 pages of historical records to reconstruct timelines and organize witness statements. Detectives used the AI to cross-reference evidence and assess Zigler’s statements during interrogation, though Lawrence emphasized that human judgment remained essential.
Investigative genetic genealogy has transformed cold case work, but experts caution about its limits and ethical concerns. David Mittelman, Othram’s CEO, compared the process to a GPS signal requiring a map built from public records and census data. However, the method requires DNA evidence and cannot solve cases without biological material.
Denise Syndercombe Court, a forensic genetics professor at King’s College London, noted privacy risks: genetic data submitted voluntarily by one individual may implicate relatives who did not consent. She also highlighted funding shortages, as many agencies rely on donations or crowdfunding to afford such services.
While the UK has a large DNA database — offering a 65% chance of matching DNA to an individual — it has not yet adopted investigative genetic genealogy. The Home Office is studying its use but has not commented publicly.
Othram has resolved thousands of cases globally, but Mittelman stressed that the technology is only one part of the process. "It can't solve every case," he said. "But it’s far more likely to yield identities than relying on chance matches in a database."
The convergence of DNA genealogy and AI marks a shift in forensic investigation, offering new pathways for unresolved crimes while raising ongoing questions about privacy, equity, and resource allocation.

